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In addition, while some studies showed that genetic and pharmacological activation of autophagy suppressed pathogenesis in a subset of disease models [84, 86, 89,90,91,92,93], others showed very limited impact on animals ataxic phenotypes, highlighting that autophagy activating drugs should be used with caution due to possible toxicity issues that may occur during chronic administration [94, 95]

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Typical weekly total: 1 mg per week , given as one injection (or split into 2)