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Although promising, the absence of blinding and placebo control limits the strength of causal inference (Shaaban et al., 2018)

Notably, LPC (16:0), a lipid oxidation product, is elevated in FM and directly activates acid-sensing ion channel 3 (ASIC3) on nociceptors, leading to hyperalgesia in animal models (13)

People who carry the genetic mutations that cause G6PD deficiency are at an increased risk for hemolytic anemia when taking certain medications, including quinine-based medication

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