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In cases of severe host immunosuppression or iatrogenic factors, C

Because methylcobalamin may be advantageous in treating chronically progressive MS as an immunosuppressive medication by enhancing oligodendrocyte maturation and clinical results [35,36,37], this study sought to collect information and review previous research on the function of Cbl in MS and to consider whether it can be applied in the future to treat this disease and its symptoms more effectively

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ROS-mediated cell signaling As outlined above, ROS have origin from two main sources: mitochondrial oxidative metabolism and processes of cellular response to xenobiotics, bacteria, and cytokines during which ROS are formed as a part of either signal transduction pathways or a cellular defense mechanism (Finkel 2011)