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Common side effects reported by the Mayo Clinic include: Diarrhea Headache Nausea If these side effects become severe or troublesome, let your healthcare provider know immediately

Patients require evaluation before starting DMARDs to rule out contraindications to the medications (meaning the patient should not take a certain medication due to the harm it would cause) and monitoring while using them to watch for serious side effects

Their ease of use and ability to act systemically make them a convenient option for research and therapeutic purposes