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Dihexa is believed to enhance brain-derived neurotrophic factor (BDNF) signaling, crucial for neuron growth and survival

The most performance-relevant outcome is improved oxygen delivery, because B12 deficiency directly causes anemia and reduced VO2 max regardless of training

While the clinical relevance of these findings in a population largely free from kidney disease remains uncertain, the reductions in albuminuria, blood pressure, and the favourable safety profile support further investigation of retatrutides potential kidney-protective effects in high-risk populations

Front Endocrinol 13:1092837 Omon EA, Ajayi OD (2023) Oxidative stress and antioxidants markers in individuals with thyroid hormones dysfunction