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Patients on anticoagulants should maintain consistent vitamin K intake and discuss any supplement changes with their healthcare provider
It should also be noted that, from a methodological perspective, the model used (Cox with stratification by cardiovascular risk class of the trials, i.e., SURPASS-4: high risk, and all others: low risk) requires various assumptions, including the homogeneity of the relative effect of tirzepatide treatment on MACE regardless of the baseline cardiovascular risk level of the patients
Pending successful completion, FDA approval could come as early as 2027, which would make retatrutide the first approved triple-agonist medication
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