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Moreover, IGF1R activated by IGF-1 plays a role in epidermal growth factor receptor (EGFR)-mediated primary or secondary resistance to colorectal cancer by upregulating the PI3K/AKT signaling pathway (16)

doi: 10.1371/journal.pone.0193114 18 Gawrys-KopczynskaM.KonopM.MaksymiukK.KraszewskaK.DerzsiL.SozanskiK.et al

Abulseoud OA, Ho MC, Choi D-S, Stanojevi A, upi , Kolar-Ani L, et al