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et al., 2023), and supplementing cofactors essential for GPX4 enzymatic activity, such as selenium (Ingold et al., 2018

Although it can affect people of all ages, it usually impacts those who are over 60-70 years of age more, with about 2% of them having it

Abbreviations 2-ME: 2-mercaptoethanol ACN: Acetonitrile BCPB: 1-benzyl-2-chloropyridinium bromide Captopril: [2 S]-1-[3-mercapto-2-methylpropionyl]-L-proline CMLT: 2-chloro-1-methyllepidinium tetrafluoroborate CMQT: 2-chloro-1-methylquinolinium tetrafluoroborate Cys: Cysteine DTT: Dithiothreitol FDA: United States Food and Drug Administration GSH: Glutathione Hcy: Homocysteine Hcy-thioalctone: Homocysteine-thiolactone HPLC-UV: High performance liquid chromatography with spectrophotometric detection LA: Lipoic acid MESNA: 2-mercaptoethanesulfonic acid MPG: N-(2-mercaptopropionyl)-glycine NAC: N-acetylcysteine N-Hcy-Lys: N-homocysteinyllysine RP-HPLC: Reverse-phase high performance liquid chromatography TCA: Trichloroacetic acid TCEP: tris(2-carboxyethyl)phosphine References Lu, S

Changes in Blood Profile from Steady State in Patients with Sickle Cell Anemia Admitted for Vaso-occlusive Crisis and Acute Chest Syndrome