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Data availability Atomic coordinates and structure factors for the crystal structures of the TRF1 TRFH domain in complex with the compounds discussed herein have been deposited in the Protein Data Bank (www.wwpdb.org) and can be accessed using the PDB accession numbers provided in Supplementary Table 3

How MOTS c Works Inside the Body MOTS c activates metabolic pathways that increase the use of glucose and fatty acids for energy

Mitochondrial DNA (mtDNA) mutations also increase with age