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Eur J Pharmacol 1981

The Variable Importance in Projection (VIP) was ranked in the OPLS-DA (orthogonal projections to latent structures discriminant analysis) based on each variables total effect on the OPLS-DA model, with variables having a VIP 1 and p 2.0.CO;2 25 KimS

This will be determined by your practitioner with assessment

Because GH and IGF-1 signaling can influence fluid balance, connective tissue, metabolism, and glucose regulation, potential GH-axis-related effects include: Water retention Peripheral edema Joint stiffness or discomfort Muscle aches Paresthesias or tingling Carpal-tunnel-like symptoms Changes in insulin sensitivity or glucose handling Adult GH replacement literature consistently identifies fluid-retention-related effects including edema, arthralgia, carpal tunnel syndrome, and paresthesias as common side effects of GH treatment