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As a fatty acid amide, PEA interacts with the peroxisome proliferator-activated receptor alpha (PPAR-$\alpha$) and G-protein coupled receptors to down-regulate mast cell activation, offering an advanced model for studying the mitigation of visceral pain and chronic neuro-inflammatory signaling along the enteric nervous system

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Reduce joint pain: Prioritize regular strength training and low-impact movement, get plenty of omega-3s, and take NSAIDs like aspirin or ibuprofen as needed or as directed by your healthcare professional

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