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Full text: #MALO #VCTE #FIB4 CUHK Medicine To view or add a comment, sign in (NASDAQ: #DNLI) The New England Journal of Medicine has published Phase 1/2 data showing Denalis Hunter syndrome drug tividenofusp alfa (DNL310) can cut cerebrospinalfluid heparan sulfate by about 90% to normal or nearnormal levels and improve or stabilize cognition, behavior, hearing, liver size, and other clinical measures in most treated children, bolstering its case for FDA priority review and potential accelerated approval

270 Class I HDACs, notably HDAC1, are redox-sensitive, potentially via Cys residues, impacting histone acetylation patterns and gene expression

She suggests treatments which are not for instant results but for long term

This could be a long-term game changer if it yields a better tolerability profile than injectable Zepbound and Wegovy