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(157) demonstrated that middle-aged K/BxN mice developed more severe arthritis and exhibited more extensive iBALT lesions compared to young mice, regardless of SFB colonization

Knockdown of one factor in the pathway may improve but not fully disrupt the muco-inflammatory cycle due to the multifactorial and overlapping regulators of mucin secretion

Relax: Leave the mask on for 1020 minutes

Model analysis Selection of parameters for estimation The methodology to select parameters for estimation involves first conducting local sensitivity analysis (LSA) to obtain a set of important parameters, and then determining from this set of parameters which are identifiable, that is for which parameters a value can be identified from the data, taking into account the model structure