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It has been reported that at least two DAMPs, namely mutant KRAS protein [172] and the DNA oxidation product 8-hydroxyguanosine/8-OHG [37], are released by ferroptotic cells to mediate macrophage polarization through the activation of AGER/RAGE (advanced glycosylation end-product specific receptor) and STING1/STING/TMEM173 (stimulator of interferon response cGAMP interactor 1) pathways, respectively

Treatment of barley spikes with the type B trichothecene deoxynivalenol (DON) led to the marked up-regulation of gene transcripts encoding e.g., GSTs

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When HNMT enzyme activity is reduced due to genetic variants, histamine can accumulate in the central nervous system, contributing to anxiety, irritability, brain fog, and sleep disruption