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By influencing sleep regulation, DSIP peptides contribute to improved sleep quality and circadian rhythm balance

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The largest share still originates from the Zagreb group, but independent contributions have accumulated notably a body of in vitro tendon-fibroblast work from investigators at Chang Gung University in Taiwan beginning in the 2010s [6], and, more recently, systematic pharmacokinetic characterization

The foundational obesity finding comes from Kraus and colleagues (Nature, 2014), who showed that knocking down NNMT protected mice against diet-induced obesity establishing NNMT as a metabolic target in the first place