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S2), this trend did not rise to the level of statistical significance

Certain medications (like anti-seizure drugs or metformin) can interfere with B-vitamin absorption

Strength points and limitations Based on our knowledge, this is the most updated meta-analysis on this topic, including all available evidence based on our inclusion criteria of including only controlled studies, either RCTs or controlled observational studies, to reach the highest accessible quality of evidence from the available evidence found in the literature

alternative protocols (e.g., 100 mcg every other day) may be selected based on clinical response and laboratory indices