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Notably, the mechanisms of probiotics may involve modulation of gut microbiota composition, while prebiotics such as inulin-type fructans (ITF) can selectively promote the growth of beneficial bacteria like Bifidobacterium and Lactobacillus, enhancing SCFA production and subsequently improving gut barrier function, insulin sensitivity, and metabolic parameters (99, 110)

Impaired growth hormone secretion in the adult population: relation to age and adiposity

Third, in some cases, publication bias has changed the overall results

In rodent work, subcutaneous administration is the route most commonly used for both compounds in published mechanistic studies