The formula also includes butylene glycol, methylpropanediol, triethylhexanoin, phenyl trimethicone, diethoxyethyl succinate, polyglyceryl-10 myristate, ethylhexylglycerin, sodium gluconate, cellulose gum, gluconolactone, biotin, thioctic acid, hyacinthus orientalis (hyacinth) extract, salvia sclarea (clary) extract, carum petroselinum (parsley) extract, hexyl cinnamal, limonene, linalool, and fragrance
Studies using animal models also have demonstrated its effectiveness in mitigating mitochondrial damage linked to oxidative stress in the lacrimal gland (Uchino et al., 2012)
Glutathione is a tri-peptide that has a gamma linkage between the first two amino acids (instead of the typical alpha linkage), which resists degradation by intracellular peptidases
One is the over-expression of GLS or GLS gene variant GLS-K325A leading to BPTES and CB-839 resistance in P493 lymphoma cell line and PC3 prostate cancer cell line respectively [58]