glutathione affinity column On and Off Protein Tag Removal The resin consists of reduced glutathione (GSH) covalently coupled to 6% cross Two-step metal affinity purification of

Chemosphere 262:127803

Although the evidence is compelling that cysteine S -conjugate -lyase reactions contribute to the nephrotoxicity of DCVC and other cysteine S -conjugates derived from halogenated alkenes, as noted earlier, the sulfoxides of the cysteine S -conjugate and mercapturates may be even more toxic than the cysteine S -conjugate (Lash et al., 1994, Lash et al., 2003, Werner et al., 1996)

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However, it is important to strike that although these data underscore the significance of GSH depletion for a short period of time (up to 24 hours), it is conceivable that depletion of GSH per se for serveral days may result in a different outcome