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514 UPR signaling in neuroinflammation, oligodendrocyte survival, and demyelination in MS ER stress is widely observed in demyelinating lesions in MS, with elevated levels of markers such as CHOP, BiP, phosphorylated PERK, phosphorylated eIF2, and XBP-1 in microglia, oligodendrocytes (OLs), T cells, and astrocytes

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Pancreatic cancer tumors have low blood flow and abundant interstitial tissue, which makes drug delivery difficult to these tumors, resulting in a low response rate to chemotherapy (5,6)