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In addition, the median time to onset of any-grade hepatic events (29.0 d), diarrhea/colitis (18.0 d), dermatitis/rash (24.0 d), and endocrine events (57.0 d) for participants who received STRIDE in our study differed when compared with the phase I/II multicohort CheckMate040 study (NCT01658878), which assessed multiple doses of nivolumab plus ipilimumab and reported an approximate median time to onset of hepatitis (39.256.7 d), diarrhea/colitis (58.8172.2 d), rash events (14.7135.8 d), and endocrine events (hyperthyroid events, hypophysitis, and hypothyroid events

[164] Patients with hepatic impairment require careful dose adjustments due to reduced melatonin clearance

Notably, abnormalities in the MMADHC protein led to the cobalamin-related disorder CblD due to the simultaneous loss of AdoCbl and MeCbl synthesis in cells and disruption of the MMACHC interaction [96, 97]

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