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The study established that FOXO4 maintains senescent cell viability by targeting p53 to the nucleus and preventing apoptosis, and that disrupting the FOXO4-p53 interaction with FOXO4-DRI causes p53 nuclear exclusion and cell-intrinsic apoptosis in ionising radiation-induced and doxorubicin-induced senescent IMR90 fibroblasts

In a transected rat sciatic nerve model (Gjurasin et al., 2010, published in Regulatory Peptides), BPC-157 promoted functional nerve reconnection and accelerated axonal sprouting, with treated animals recovering motor function significantly faster than controls

doi: 10.1016/j.freeradbiomed.2016.10.438 144 SantaellaA.KuiperijH

GHK-Cu can degrade when exposed to air, light, or improper pH levels