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To minimize age-related confounding, we adjusted health deficit scores for age prior to analysis and used the residual values for the piecewise regression

doi: 10.1038/s41580-020-00324-8 130 RatliffBBAbdulmahdiWPawarRWolinMS

This methylation is crucial to regulate gene expression, neurotransmitter synthesis, myelin formation, and the methylation of histones and DNA (70, 77)