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reported that the expression level of asparagine synthetase (ASNS) in breast cancer is closely related to metastatic recurrence and that inhibition of ASNS or restriction of dietary Asn can reduce tumor metastasis

Despite these numerous advantages, inhaled drug delivery encounters considerable barriers that limit its overall effectiveness 13,114 (Fig

Ferroptosis susceptibility and impact on tumor growth differ between cancer types [204] and even within the same cancer type the protective ferroptotic pathway can change as shown for melanoma cells in which protection against ferroptosis shifts from GPX4 to FSP1 during lymphatic metastasis [205]