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Although the aged brain does have increases in ROS, pro-inflammatory cytokines, and a general reduction in glial cell function, the extent of these changes and the dynamics at play are inherently different than those observed after the application of LPS or experimentally-induced demyelination at younger ages

GHK-Cu applied immediately post-needling penetrates deeply and dramatically amplifies the collagen induction response

described a redox-uptake system mediated by gliotoxin [55]: intracellular gliotoxin can be reduced to dithiol gliotoxin by a cellular reducing agent, thus releasing electrons to cellular O 2 to form O 2 -mediated gliotoxin, which can yield ROS

10.1046/j.1432-1033.2003.03880.x