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the average response rate for chemotherapy, which is more like 3-10%)

No pharmaceutical company, no academic medical center, and no government agency has found the existing preclinical data compelling enough to fund a rigorous human trial in over 30 years

Multiple cellular processes are considered to contribute to this functional decline and these are collectively referred to as the hallmarks of aging and these include processes like genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis 1

That is a genetic-knockdown study in mice, not a drug trial: it tells you the target is real and metabolically meaningful in an animal model, but it does not test a drug, a dose, or a route