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[Abstract]2020 Dec 31:rs.3.rs-100914

revealed that knockout of arachidonate 12-lipoxygenase (ALOX12) specifically blocked the occurrence of ferroptosis, which proved that p53 indirectly activated the function of ALOX12 by inhibiting SLC7A11, resulting in ALOX12-dependent ferroptosis after ROS stress (Chu et al., 2019)