Multiple studies have shown that vitamin E levels are significantly reduced in cirrhotic patients and decline with worsening disease severity [44, 45]
Covalent functionalisation forms stable bonds via amidation, esterification, or silylation, ensuring durable conjugation for drugs, proteins, or imaging agents, whereas non-covalent approaches rely on stacking, electrostatic interactions, adsorption, or chelation, ensuring reversible binding, well-suited for stimuli-responsive delivery [33]
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Clin Biochem 44:119135 Rudneva II, Skuratovskaya EN, Kuzminova NS, Kovyrshina TB (2010) Age composition and antioxidant enzyme activities in blood of Black Sea teleosts