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A similar dietary supplementation was also found to decrease the phosphorylation of PPAR and nuclear factor E2-related factor 2 (Nrf2) and induce upregulation of their downstream targets including -glutathione S-transferase (GST) and adenosine triphosphate-binding cassette transporter A1 (ABCA1) through inhibition of matrix metalloproteinase-1 (MMP-1) (Bozaykut et al., 2014)

A number of factors are at play poor nutrition and processed foods, excess stress, environmental toxins, cleaning supplies and chemicals, and drinking alcohol all tax our supply of glutathione

Deletion of OPA1 induces mitochondrial fragmentation and cell death, as demonstrated in MOLM-14 cells [77]

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