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Therefore, current efforts in radiation research have aimed to devise strategies that will make tumor tissue more sensitive to ionizing radiation while protecting normal cells

The most commonly acknowledged serotonin presentation can be from the enterochromaffin cells out of tissues into the blood, secreted luminally and basolaterally increased serotonin uptake by circulating platelets and activation after stimulation, toward the increased stimulation of myenteric and gastrointestinal motility [187]

Under oxidation conditions, TRPV1 can overexpress tumor necrosis factor receptor 1 (TNFR1) in DRG cells through a ROS-mediated signaling pathway, which could bind with proinflammatory cytokine tumor necrosis factor (TNF-) to increase inflammatory conditions and nociception (Westlund et al., 2010)

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