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To determine a causal role between senescent cells and tauopathy, we administered intermittent (once every two weeks) senolytic therapy (D+Q) to tau transgenic mice between the ages of 20-23 months old with already present tau pathology, neurodegeneration, inflammation and brain atrophy (35)

Finally, while CRISPR/Cas9 technology has been employed to remove the polyQ tract of ATXN3 in iPSCs [289], no preclinical trials in rodents have been published