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Claudin-2 is selectively enriched in and promotes the formation of breast cancer liver metastases through engagement of integrin complexes

Limitations of a Symptom-Suppression Pain Model While medications and injections may reduce pain temporarily, they often: Do not correct structural imbalance or tissue degeneration Fail to resolve inflammatory or immune-driven pain Overlook metabolic contributors such as blood sugar instability or nutrient depletion Ignore nervous system sensitization and central pain amplification that perpetuate chronic pain As a result, pain frequently returnssometimes requiring higher doses, repeated injections, or additional medications to maintain relief

Stefan, M., et al

The MS/MS raw data were processed using SpectroMine software (v4.2.230428.52329) with the built-in Pulsar search engine against the UniProt FASTA database for peptide identification 66