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Data availability The Cryo-EM density maps and associated masks have been deposited in the EMDB under accession number EMD-63371, EMD-63372, EMD-63374, EMD-63375, EMD-63397, EMD-63383, EMD-63385, and EMD-63386, EMD-63565, and EMD-65758

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[39] Paracetamol poisoning is one of the leading causes of poisoning in high-income countries, [40] and the foremost cause of acute liver failure in many countries

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