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They are essential to the production of certain bodily compounds

PMID: 27730033 Costa CS, (2018) Oral isotretinoin for acne. Cochrane Database Syst Rev

HuangJChenPXiangYLiangQWuTLiuJet al

Because there is limited hemorrhage in human livers after an APAP overdose, the C57Bl/6J strain is more relevant for the human pathophysiology than mouse strains that develop extensive hemorrhagic shock [131]