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Importantly, the proteomic similarity of Day 30 iHLOs to PHHs, with a 33.46% expression difference from liver tissue, underscores their physiological relevance compared to traditional models like HepG2 cells, which exhibit a 54.36% protein difference from liver tissue, or HepaRG cells, with a 45.40% protein difference

3 younger adults and 2 older adults were left-handed, and one older adult was ambidextrous

The hydrolysis by lipase resulted in the release of unsaturated fatty acids, and the vesicular cytotoxicity of unsaturated linoleate, oleate, and linolenate esters ultimately contributed to pancreatic inflammatory response and necrosis [45]

When its oxidized, glutathione is inactive and cannot fulfill its role as an antioxidant