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SAMe is important for making neurotransmitters and controlling gene expression

Different reconstitution volumes produce different concentrations from the same vial: 50mg vial + 2ml water = 25mg/ml (very concentrated) 50mg vial + 2.5ml water = 20mg/ml (concentrated) 50mg vial + 5ml water = 10mg/ml (standard) 50mg vial + 10ml water = 5mg/ml (dilute) Higher concentrations require smaller injection volumes but may exceed solubility limits for some peptides

This may be due to damage induced by inadequate B12 supply and affecting brain function, becoming irreversible after a certain period of time