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hTERT expression and telomerase activity were then quantified in cells treated with the tetrapeptide

A comprehensive evaluation of various factors, including the dosage of the medication, the administration route, the specific type of hormonal agent utilized (whether combined estrogen or progestin), the timing of treatment initiation, the patients age, her cardiovascular disease history, and the thromboembolic characteristics associated with estrogen and progestin, is essential for postmenopausal hormone replacement therapy (171)