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This mechanism explains why retatrutide shows different outcomes than semaglutide in research settings and why comparisons with tirzepatide consistently show the triple agonist producing more pronounced effects across multiple endpoints

Many patients experience a positive response within 24 hours, although 3 to 4 weekly treatments may be necessary for sustained results

This data is reported separately in the results

Cerebral pharmacokinetics and microdialysis To confirm that a peptide actually reaches its cerebral target, microdialysis remains the reference tool: Principle : insertion of a semi-permeable membrane probe in a target region (hippocampus, frontal cortex)