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This estimator correlated negatively with age in different tissues and in various cell types and outperformed LTL measurements generated using classical Southern Blot-based approach when predicting morbidity and mortality

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Charles Brenner, who discovered nicotinamide riboside as an NAD+ precursor, conducted a 2016 clinical trial showing oral NR supplementation safely increased human blood NAD+ levels up to 2.7-fold [14]

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