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This decline is often linked to the general increase in oxidative stress that happens over time

Oral BPC-157 is also used, though bioavailability is lower than subcutaneous, and higher doses may be needed to achieve equivalent systemic effects

A 2019 study in the British Journal of Clinical Pharmacology found that a single 800 mg EGCG dose decreased midazolam (a CYP3A4 probe) AUC by approximately 18% in healthy volunteers, suggesting meaningful CYP3A4 modulation [9]

BPC-157 demonstrates systemic effects even from gastric administration in some models, but localized vascular repair often requires direct proximity to the injury site