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Indeed, brain hub regions in humans do exhibit a spatiotemporally distinctive transcriptomic pattern dominated by genes associated with metabolic processes, including those with oxidoreductase activity (e.g., GPx) (Xu et al., 2022)

The dose is high because oral bioavailability is low, and there's no penalty for pushing it

Guerra BA, Bolin AP, Morandi AC, Otton R (2012) Glycolaldehyde impairs neutrophil biochemical parameters by an oxidative and calcium-dependent mechanismProtective role of antioxidants astaxanthin and vitamin C

On the role of synthesized hydroxylated chalcones as dual functional amyloid-beta aggregation and ferroptosis inhibitors for potential treatment of Alzheimers disease