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The histological characteristics of IC, including the thinning and erosion of the bladder epithelium, along with heightened infiltration by mast cells, suggest that the condition may stem from the compromised regenerative capacity of the bladders epithelial cells, coupled with anomalies in immune system functioning (Slobodov et al., 2004)

Although several studies have demonstrated the efficacy of RSL3 in various animal models (31, 32), non-specific effects of RSL3 cannot be excluded given its poor bioavailability in vivo ( To date, the majority of studies regarding drug-tolerant persister cells have focused on persister cells from immortalized cell lines, demonstrating that they occur as a small subset of the total tumor population (33)

10.1155/2022/3112388 100 LoughlinJ