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Circ Res 107(10):12201231 Norton N, Li D, Rieder MJ, Siegfried JD, Rampersaud E, Zchner S, Mangos S, Gonzalez-Quintana J, Wang L, McGee S, Reiser J, Martin E, Nickerson DA, Hershberger RE (2011) Genome-wide studies of copy number variation and exome sequencing identify rare variants in BAG3 as a cause of dilated cardiomyopathy

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Renal impairment was thought to be caused by the precipitation of MTX and its metabolites in the renal tubules

The added signal peptides help reinforce these processes, resulting in firmer, smoother-looking skin with continued use