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On the other hand, TB-500 mediated cytoskeletal regulation can influence additional signaling networks because actin dynamics are closely linked to cell adhesion, migration signaling, and intracellular transport pathways [7]
(73) showed in PC-3 cells that LPA (18:1) pretreatment inhibits ionomycin-induced focal adhesion kinase (FAK) and p130CAS degradation, reducing cell detachmentan effect dependent on LPA receptors and paxillin phosphorylation
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