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If a patient is suspected to be experiencing OIH, carefully consider appropriately decreasing the dose of the current opioid analgesic or opioid rotation (safely switching the patient to a different opioid moiety) [see DOSAGE AND ADMINISTRATION, WARNINGS]

For example, as discussed above, we assume that normally 10% per hour of the cysteine, glycine, and glutamate in the blood is taken up by other cells and that an additional 25% of cysteine in the blood is lost by conversion to cystine

The results indicated lower XO activity in patients experiencing adverse effects

You are in complete control of the final concentration