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Safety Considerations & Provider-Directed Sequencing Concurrent GIP/GLP-1 agonist therapy with high-dose antioxidant support is not yet extensively studied in large randomized trials

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However, in the spontaneously hypertensive rat model, the expression of myostatin protein decreased in chronically hypertrophic myocardium and was significantly negatively correlated with left ventricular diastolic diameter/body weight ratio and left ventricular systolic diameter, but positively correlated with partial shortening of the middle wall (75)

It is found that in the clinical follow-up studies of NAFLD patients, compared with the control group, hepatic fat content and ALT levels were not significantly reduced in Lira group and were associated with an increased incidence of gastrointestinal adverse events [118]