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Dietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex

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It is needed for energy production through the Krebs Cycle, for the synthesis of DNA via the folate cycle which affects trillions of cells in the body, and for the expression of genes through epigenetic processes

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At specified time intervals, metabolism was terminated by precipitating proteins with the addition of 1ml of a solution of acetonitrile (ACN) and acetic acid (9: 1 , v/v)

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