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These subjective improvements correlate with objective sleep architecture changes measurable through polysomnography sleep studies showing increased slow-wave sleep percentage, improved sleep efficiency (time actually asleep vs time in bed), reduced wake after sleep onset episodes, and better maintenance of natural circadian rhythms through optimized growth hormone pulsatility

A previous study has also demonstrated that systemic administration of KA induces contraction and even death of piriform cortical neurons

These typically resolve within hours to days and diminish with repeated doses