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The exact minimum effective concentration that recapitulates our observed suppressive ILC2 phenotype in vivo , remains to be determined, and will likely rely on a complex grouping of factors that take into account systems with endogenous melatonin rhythms (such that were absent in our studies both in vitro and in vivo with BALBc mice)

The working hypothesis, discussed in the Giblin et al

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Unlike fat-soluble vitamins that require fat for absorption and are stored in the liver, water-soluble vitamins like B12 are processed more quickly by the body and are not stored for long-term use