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The disease spectrum of NAFLD includes non-alcoholic fatty liver, also known as simple fatty liver, non-alcoholic fatty hepatitis, fatty liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC) ( Many preclinical studies have shown that caffeine intake alleviates NAFLD and can even prevent NAFLD in high-fat-diet (HFD)-fed mice ( / and HFD-fed WT mice
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